Search results for "functional similarity"
showing 4 items of 4 documents
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
2013
To access publisher's full text version of this article click on the hyperlink at the bottom of the page Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation. We compared 3,789 PSC cases of European ancestry to 25,079 population controls across 130,422 SNPs genotyped using the Immunochip. We identified 12 genome-wide significant associations outside the human leukocyte antigen (HLA) complex, 9 of which were new, increasing the number of known PSC risk loci to 16. Despite comorbidity with inflammatory bowel disease (IBD) in 72% of the cases, 6 of the 12 loci sh…
SIMILARITY NETWORK FOR SEMANTIC WEB SERVICES SUBSTITUTION
2013
Web services substitution is one of the most challenging tasks for automating the composition process of multiple Web services. It aims to improve performances and to deal efficiently with Web services failures. Many existing solutions have approached the problem through classification of substitutable Web services. To go a step further, we propose in this paper a network based approach where nodes are Web services operations and links join similar operations. Four similarity measures based on the comparison of input and output parameters values of Web services operations are presented. A comparative evaluation of the topological structure of the corresponding networks is performed on a ben…
Linking species interactions with phylogenetic and functional distance in European bird assemblages at broad spatial scales
2017
Aim: Understanding the relative contribution of different species interactions in shaping community assembly has been a pivotal aim in community ecology. Biotic interactions are acknowledged to be important at local scales, although their signal is assumed to weaken over longer distances. We examine the relationship between positive, neutral and negative pairwise bird abundance distributions and the phylogenetic and functional distance between these pairs after first controlling for habitat associations. Location: France and Finland. Time period: 1984 to 2011 (Finland), 2001 to 2012 (France). Major Taxa studied: Birds. Methods: We used results from French and Finnish land bird monitoring pr…
Striato-amygdaloid transition area lesions reduce the duration of tonic immobility in the lizard Podarcis hispanica.
2002
Neuroanatomical data suggest that the lizard striato-amygdaloid transition area is homologous with the mammalian central amygdala. In order to investigate possible functional similarities, tonic immobility was induced in adult lizards and its duration recorded. Each lizard was then randomly assigned to one of three treatments: (1) bilateral striato-amygdaloid transition area lesions, (2) bilateral dorsal cortex lesions or (3) untreated controls. Three days after trial 1, each lizard was subjected to a second trial and the tonic immobility duration recorded. The mean tonic immobility duration in lizards with striato-amygdaloid transition area lesions was significantly shorter (80.5%; p < 0.0…